CMap Candidate Details

Structure:
CMap ID: C01876
Pert ID: BRD-A76747559
Compound Name: rutin
Targets: AKR1C3
MoA: Antioxidant; Nitric oxide scavenger; Capillary stabilizing agent
SMILES: C[C@@H]1O[C@@H](OC[C@H]2OC(Oc3c(oc4cc(O)cc(O)c4c3=O)-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
InchiKey: IKGXIBQEEMLURG-KUKMIBIMSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127021 BRD-A76747559 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127069 BRD-A76747559 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127103 BRD-A76747559 HELA 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
127213 BRD-A76747559 MCF??7.00 3.33 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
127242 BRD-A76747559 PC3 3.33 uM 24 h -0.22 -0.93 0.07 0.0 0.0 0.0
127317 BRD-A76747559 YAPC 0.37 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
135045 BRD-A76747559 A549 0.03 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.59
135086 BRD-A76747559 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135148 BRD-A76747559 HT29 0.74 uM 24 h -0.23 -0.95 0.09 -0.23 -0.78 0.09
135174 BRD-A76747559 JURKAT 0.03 uM 24 h -0.25 -1.05 0.23 0.24 0.85 0.14
135208 BRD-A76747559 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135269 BRD-A76747559 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135308 BRD-A76747559 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).