CMap Candidate Details

Structure:
CMap ID: C18770
Pert ID: BRD-K51313569
Compound Name: palbociclib
Targets: CDK4; CDK6
MoA: CDK inhibitor
SMILES: CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O
InchiKey: AHJRHEGDXFFMBM-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
34123 BRD-K51313569 ASC 10 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.39
34639 BRD-K51313569 HCC515 10 uM 6 h 0.0 0.0 0.0 0.29 1.02 0.48
34904 BRD-K51313569 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36282 BRD-K51313569 PHH 10 uM 24 h 0.23 0.97 0.08 -0.23 -0.78 0.1
36582 BRD-K51313569 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36832 BRD-K51313569 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91578 BRD-K51313569 HS578T 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91656 BRD-K51313569 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
91753 BRD-K51313569 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
92405 BRD-K51313569 A375 0.37 uM 24 h -0.24 -1.0 0.15 -0.25 -0.86 0.2
92430 BRD-K51313569 A549 1.11 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
92460 BRD-K51313569 BT20 0.12 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
92527 BRD-K51313569 HME1 0.12 uM 24 h 0.25 1.05 0.16 -0.22 -0.73 0.05
92625 BRD-K51313569 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92661 BRD-K51313569 LNCAP 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.15
92728 BRD-K51313569 MCF10A 0.04 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92770 BRD-K51313569 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95384 BRD-K51313569 U2OS 1.11 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
95855 BRD-K51313569 NPC 0.5 uM 6 h -0.21 -0.86 0.02 -0.25 -0.85 0.19
95966 BRD-K51313569 PC3 0.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
97309 BRD-K51313569 HAP1 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.6
124396 BRD-K51313569 JURKAT 10 uM 24 h -0.31 -1.31 0.82 -0.25 -0.84 0.18
132374 BRD-K51313569 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132406 BRD-K51313569 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132437 BRD-K51313569 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132583 BRD-K51313569 THP1 2.22 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
132634 BRD-K51313569 YAPC 2.22 uM 24 h 0.32 1.35 0.94 -0.4 -1.35 1.86
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).