CMap Candidate Details

Structure:
CMap ID: C18864
Pert ID: BRD-K51575138
Compound Name: TPCA-1
Targets: IKBKB
MoA: IKK inhibitor
SMILES: NC(=O)Nc1sc(cc1C(N)=O)-c1ccc(F)cc1
InchiKey: SAYGKHKXGCPTLX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9437 BRD-K51575138 AGS 10 uM 6 h -0.25 -1.02 0.18 0.0 0.0 0.0
9740 BRD-K51575138 H1299 10 uM 6 h 0.0 0.0 0.0 0.24 0.84 0.12
10060 BRD-K51575138 HA1E 10 uM 6 h 0.23 0.97 0.08 0.0 0.0 0.0
10197 BRD-K51575138 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10530 BRD-K51575138 HCT116 10 uM 6 h 0.0 0.0 0.0 0.24 0.85 0.14
11502 BRD-K51575138 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11776 BRD-K51575138 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12064 BRD-K51575138 NCIH596 10 uM 6 h -0.33 -1.38 1.08 -0.32 -1.07 0.75
12329 BRD-K51575138 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12804 BRD-K51575138 SW480 10 uM 6 h 0.0 0.0 0.0 -0.2 -0.66 0.01
13287 BRD-K51575138 U937 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.4
13631 BRD-K51575138 VCAP 10 uM 6 h 0.21 0.86 0.01 0.0 0.0 0.0
90683 BRD-K51575138 MCF10A 10 uM 24 h 0.18 0.76 0.0 -0.26 -0.88 0.24
91810 BRD-K51575138 HS578T 10 uM 6 h 0.0 0.0 0.0 -0.22 -0.74 0.05
91939 BRD-K51575138 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 -0.27 -0.89 0.27
92886 BRD-K51575138 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92914 BRD-K51575138 ASC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92971 BRD-K51575138 CD34 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.21
93062 BRD-K51575138 HEK293 10 uM 24 h 0.0 0.0 0.0 0.21 0.74 0.03
93112 BRD-K51575138 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93151 BRD-K51575138 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93198 BRD-K51575138 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93340 BRD-K51575138 MDAMB231 3.33 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
93381 BRD-K51575138 NPC 0.04 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
93503 BRD-K51575138 SKL 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93527 BRD-K51575138 THP1 10 uM 24 h -0.22 -0.91 0.05 0.32 1.14 0.87
93568 BRD-K51575138 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
98057 BRD-K51575138 P1A82 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99630 BRD-K51575138 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
115637 BRD-K51575138 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115846 BRD-K51575138 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119746 BRD-K51575138 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
119788 BRD-K51575138 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119821 BRD-K51575138 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).