CMap Candidate Details

Structure:
CMap ID: C01889
Pert ID: BRD-A77216878
Compound Name: manumycin-a
Targets: FNTA; IKBKB
MoA: NFKB pathway inhibitor; Farnesyltransferase inhibitor
SMILES: CCCC[C@@H](C)C=C(C)C=C(/C)C(=O)NC1=C[C@@](O)(C=CC=CC=CC(=O)NC2C(=O)CCC2=O)[C@@H]2OC2C1=O
InchiKey: XIZGHTZLVCHYJN-YCWSEAROSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9152 BRD-A77216878 A549 10 uM 6 h -0.23 -0.95 0.09 0.0 0.0 0.0
9311 BRD-A77216878 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10339 BRD-A77216878 HCC515 10 uM 6 h 0.23 0.94 0.06 0.0 0.0 0.0
10418 BRD-A77216878 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10690 BRD-A77216878 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11366 BRD-A77216878 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11673 BRD-A77216878 NCIH508 10 uM 6 h 0.18 0.76 0.0 0.0 0.0 0.0
11935 BRD-A77216878 NCIH596 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.38
12687 BRD-A77216878 SW480 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.24 1.35
13550 BRD-A77216878 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87298 BRD-A77216878 BJAB 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87342 BRD-A77216878 HBL1 0.04 uM 24 h 0.0 0.0 0.0 -0.2 -0.68 0.02
87393 BRD-A77216878 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87440 BRD-A77216878 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87515 BRD-A77216878 MINO 0.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
87544 BRD-A77216878 NALM6 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87595 BRD-A77216878 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
87644 BRD-A77216878 OCILY19 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87696 BRD-A77216878 OCILY3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87744 BRD-A77216878 SKMEL5 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87815 BRD-A77216878 THP1 0.66 uM 6 h -0.22 -0.9 0.04 0.0 0.0 0.0
87844 BRD-A77216878 TMD8 0.125 uM 3 h -0.31 -1.3 0.82 0.0 0.0 0.0
97688 BRD-A77216878 NKDBA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124280 BRD-A77216878 A375 1.11 uM 24 h 0.25 1.06 0.18 0.27 0.97 0.34
124326 BRD-A77216878 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124364 BRD-A77216878 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124433 BRD-A77216878 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.53
124455 BRD-A77216878 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124470 BRD-A77216878 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124496 BRD-A77216878 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124526 BRD-A77216878 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124556 BRD-A77216878 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132398 BRD-A77216878 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132470 BRD-A77216878 HT29 0.08 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).