CMap Candidate Details

Structure:
CMap ID: C18894
Pert ID: BRD-K51677086
Compound Name: erythromycin-ethylsuccinate
Targets: CYP3A4; CYP51A1; ALB; MLNR; KCNH2; ABCB1; SLC47A1
MoA: NFKB pathway inhibitor; Motilin receptor agonist; Cytochrome P450 inhibitor; Protein synthesis inhibitor
SMILES: CCOC(=O)CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C
InchiKey: NSYZCCDSJNWWJL-YXOIYICCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5644 BRD-K51677086 HCC515 10 uM 24 h 0.21 0.86 0.01 -0.2 -0.69 0.02
6373 BRD-K51677086 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
44986 BRD-K51677086 ASC 10 uM 24 h 0.21 0.89 0.02 0.26 0.93 0.27
45279 BRD-K51677086 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
46102 BRD-K51677086 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46416 BRD-K51677086 PHH 10 uM 24 h 0.29 1.21 0.46 0.0 0.0 0.0
46741 BRD-K51677086 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97298 BRD-K51677086 HAP1 3.33 uM 24 h -0.23 -0.95 0.09 0.26 0.92 0.25
97361 BRD-K51677086 A375 3.33 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
124339 BRD-K51677086 HELA 1.11 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
124400 BRD-K51677086 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124460 BRD-K51677086 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
124535 BRD-K51677086 YAPC 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132350 BRD-K51677086 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132378 BRD-K51677086 HA1E 0.25 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
132410 BRD-K51677086 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
132455 BRD-K51677086 HT29 0.74 uM 24 h -0.22 -0.9 0.04 0.23 0.8 0.08
132483 BRD-K51677086 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.21
132544 BRD-K51677086 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.68
132566 BRD-K51677086 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132588 BRD-K51677086 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).