CMap Candidate Details

Structure:
CMap ID: C18911
Pert ID: BRD-K51747290
Compound Name: hydroxyurea
Targets: RRM1; RRM2
MoA: Ribonucleoside reductase inhibitor
SMILES: NC(=O)NO
InchiKey: VSNHCAURESNICA-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95358 BRD-K51747290 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 0.29 1.04 0.53
95446 BRD-K51747290 U2OS 10 uM 6 h 0.23 0.95 0.06 0.0 0.0 0.0
96995 BRD-K51747290 A375 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115676 BRD-K51747290 A549 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115755 BRD-K51747290 HCC515 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115798 BRD-K51747290 HEPG2 1.11 uM 24 h -0.19 -0.81 0.0 -0.3 -1.02 0.59
115845 BRD-K51747290 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124340 BRD-K51747290 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124401 BRD-K51747290 JURKAT 0.04 uM 24 h -0.24 -1.01 0.17 0.0 0.0 0.0
124478 BRD-K51747290 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124509 BRD-K51747290 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132379 BRD-K51747290 HA1E 0.01 uM 24 h 0.3 1.25 0.56 0.0 0.0 0.0
132411 BRD-K51747290 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.22 0.76 0.05
132484 BRD-K51747290 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.26 -0.89 0.26
132589 BRD-K51747290 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132636 BRD-K51747290 YAPC 0.08 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).