CMap Candidate Details

Structure:
CMap ID: C18929
Pert ID: BRD-K51781482
Compound Name: BRD-K51781482
Targets: --
MoA: --
SMILES: COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C#N)c2cc1OC
InchiKey: LDTAHRLHGHFHKP-UHFFFAOYSA-N
Compound Aliases: IKK3-inhibitor-IX

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8950 BRD-K51781482 A375 6.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9209 BRD-K51781482 A549 6.66 uM 6 h -0.17 -0.7 0.0 -0.26 -0.87 0.24
9438 BRD-K51781482 AGS 6.66 uM 6 h 0.0 0.0 0.0 -0.34 -1.15 1.07
9741 BRD-K51781482 H1299 6.66 uM 6 h 0.0 0.0 0.0 -0.27 -0.91 0.3
9943 BRD-K51781482 HA1E 6.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10531 BRD-K51781482 HCT116 6.66 uM 6 h -0.16 -0.67 0.0 0.27 0.94 0.3
11503 BRD-K51781482 NCIH2073 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11777 BRD-K51781482 NCIH508 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13040 BRD-K51781482 THP1 6.66 uM 6 h 0.28 1.18 0.39 0.0 0.0 0.0
13288 BRD-K51781482 U937 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13632 BRD-K51781482 VCAP 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
117793 BRD-K51781482 HCC515 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117843 BRD-K51781482 HEPG2 10 uM 24 h 0.32 1.35 0.94 0.0 0.0 0.0
117894 BRD-K51781482 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
117941 BRD-K51781482 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117988 BRD-K51781482 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).