CMap Candidate Details

Structure:
CMap ID: C01893
Pert ID: BRD-A77299732
Compound Name: salubrinal
Targets: EIF2S1
MoA: Eukaryotic translation initiation factor inhibitor
SMILES: ClC(Cl)(Cl)C(NC(=O)C=Cc1ccccc1)NC(=S)Nc2cccc3cccnc23
InchiKey: LCOIAYJMPKXARU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6691 BRD-A77299732 A375 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
6955 BRD-A77299732 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7264 BRD-A77299732 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7591 BRD-A77299732 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7806 BRD-A77299732 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8224 BRD-A77299732 MCF??7.00 10 uM 6 h -0.3 -1.24 0.67 0.0 0.0 0.0
8472 BRD-A77299732 PC3 10 uM 6 h 0.17 0.72 0.0 0.0 0.0 0.0
8780 BRD-A77299732 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.12 0.95
100329 BRD-A77299732 U2OS 10 uM 6 h -0.26 -1.07 0.27 0.3 1.08 0.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).