CMap Candidate Details

Structure:
CMap ID: C18986
Pert ID: BRD-K51967704
Compound Name: BIIB-021
Targets: HSP90AA1
MoA: HSP inhibitor
SMILES: COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C
InchiKey: QULDDKSCVCJTPV-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
30207 BRD-K51967704 A549 10 uM 6 h 0.0 0.0 0.0 0.23 0.83 0.11
30466 BRD-K51967704 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
31062 BRD-K51967704 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31368 BRD-K51967704 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31882 BRD-K51967704 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32193 BRD-K51967704 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32447 BRD-K51967704 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
32646 BRD-K51967704 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33050 BRD-K51967704 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33301 BRD-K51967704 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
124344 BRD-K51967704 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124405 BRD-K51967704 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.06
124446 BRD-K51967704 MCF10A 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124482 BRD-K51967704 MDAMB231 0.04 uM 24 h -0.24 -1.0 0.14 -0.24 -0.8 0.12
132323 BRD-K51967704 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132381 BRD-K51967704 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132413 BRD-K51967704 HEK293 0.08 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
132457 BRD-K51967704 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132593 BRD-K51967704 THP1 0.74 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
132638 BRD-K51967704 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.4 1.41 2.19
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).