CMap Candidate Details

Structure:
CMap ID: C00190
Pert ID: BRD-A07563059
Compound Name: bopindolol
Targets: ADRB1; ADRB2
MoA: Adrenergic receptor antagonist
SMILES: Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1
InchiKey: UUOJIACWOAYWEZ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91175 BRD-A07563059 HUH7 8 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
122555 BRD-A07563059 A375 0.04 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
122686 BRD-A07563059 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122733 BRD-A07563059 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.24
122776 BRD-A07563059 MDAMB231 1.11 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
122800 BRD-A07563059 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.28 0.99 0.41
122821 BRD-A07563059 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130890 BRD-A07563059 A549 0.08 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
130921 BRD-A07563059 HA1E 0.01 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
130941 BRD-A07563059 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130975 BRD-A07563059 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131055 BRD-A07563059 HUVEC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131090 BRD-A07563059 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).