CMap Candidate Details

Structure:
CMap ID: C19005
Pert ID: BRD-K52020312
Compound Name: metronidazole
Targets: CYP2C9; CYP3A4
MoA: DNA inhibitor
SMILES: Cc1ncc(n1CCO)[N+]([O-])=O
InchiKey: VAOCPAMSLUNLGC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24679 BRD-K52020312 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25520 BRD-K52020312 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
53032 BRD-K52020312 HEPG2 12 uM 48 h 0.27 1.11 0.25 0.27 0.96 0.34
53080 BRD-K52020312 MCF10A 100 uM 24 h 0.28 1.15 0.34 0.0 0.0 0.0
91228 BRD-K52020312 HUH7 20 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99633 BRD-K52020312 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121558 BRD-K52020312 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121597 BRD-K52020312 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121635 BRD-K52020312 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121659 BRD-K52020312 HT29 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121678 BRD-K52020312 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
121702 BRD-K52020312 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129688 BRD-K52020312 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).