CMap Candidate Details

Structure:
CMap ID: C19254
Pert ID: BRD-K52850071
Compound Name: WHI-P154
Targets: EGFR; JAK3
MoA: JAK inhibitor
SMILES: COc1cc2ncnc(Nc3ccc(O)c(Br)c3)c2cc1OC
InchiKey: CBIAKDAYHRWZCU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1588 BRD-K52850071 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1922 BRD-K52850071 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2400 BRD-K52850071 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2782 BRD-K52850071 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.8 0.12
41787 BRD-K52850071 A375 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.55
41948 BRD-K52850071 A549 10 uM 24 h 0.0 0.0 0.0 0.29 1.04 0.56
42388 BRD-K52850071 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42708 BRD-K52850071 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43011 BRD-K52850071 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43328 BRD-K52850071 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43575 BRD-K52850071 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43876 BRD-K52850071 PHH 10 uM 24 h -0.28 -1.15 0.44 -0.34 -1.16 1.11
44133 BRD-K52850071 SKB 10 uM 24 h -0.32 -1.32 0.83 0.26 0.93 0.27
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).