CMap Candidate Details

Structure:
CMap ID: C19273
Pert ID: BRD-K52911425
Compound Name: GDC-0941
Targets: PIK3CG
MoA: PI3K inhibitor
SMILES: CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1
InchiKey: LHNIIDJUOCFXAP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
37 BRD-K52911425 BJAB 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
107 BRD-K52911425 HBL1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
116 BRD-K52911425 K562 2.5 uM 24 h 0.22 0.92 0.04 0.0 0.0 0.0
178 BRD-K52911425 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
200 BRD-K52911425 NALM6 0.66 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
239 BRD-K52911425 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
311 BRD-K52911425 OCILY19 10 uM 4 h 0.0 0.0 0.0 -0.21 -0.71 0.03
318 BRD-K52911425 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
377 BRD-K52911425 SKMEL5 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
396 BRD-K52911425 THP1 2.5 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.48
453 BRD-K52911425 TMD8 10 uM 4 h 0.28 1.16 0.35 0.0 0.0 0.0
33559 BRD-K52911425 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33913 BRD-K52911425 A549 10 uM 6 h -0.26 -1.08 0.29 0.26 0.91 0.23
34125 BRD-K52911425 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34379 BRD-K52911425 HA1E 10 uM 6 h 0.0 0.0 0.0 0.26 0.93 0.28
34641 BRD-K52911425 HCC515 10 uM 6 h -0.18 -0.75 0.0 0.0 0.0 0.0
34907 BRD-K52911425 HEPG2 10 uM 6 h -0.22 -0.91 0.05 0.37 1.32 1.6
35391 BRD-K52911425 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.23 0.8 0.08
35581 BRD-K52911425 NEU 10 uM 24 h 0.27 1.13 0.29 0.0 0.0 0.0
35799 BRD-K52911425 NPC 10 uM 24 h -0.33 -1.38 1.08 0.0 0.0 0.0
35968 BRD-K52911425 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36585 BRD-K52911425 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36834 BRD-K52911425 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91606 BRD-K52911425 HS578T 10 uM 6 h -0.25 -1.04 0.21 0.0 0.0 0.0
91741 BRD-K52911425 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.16 -0.54 0.0
92457 BRD-K52911425 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92658 BRD-K52911425 LNCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92725 BRD-K52911425 MCF10A 0.12 uM 3 h 0.0 0.0 0.0 0.3 1.05 0.58
92768 BRD-K52911425 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96046 BRD-K52911425 PHH 10 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
96070 BRD-K52911425 HME1 20 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129603 BRD-K52911425 HELA 2.22 uM 24 h 0.2 0.83 0.0 -0.23 -0.77 0.08
129634 BRD-K52911425 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129726 BRD-K52911425 YAPC 2.22 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).