CMap Candidate Details

Structure:
CMap ID: C19419
Pert ID: BRD-K53414658
Compound Name: tivozanib
Targets: FLT1; FLT4; KDR; KIT; PDGFRA; PDGFRB
MoA: VEGFR inhibitor
SMILES: COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
InchiKey: SPMVMDHWKHCIDT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9441 BRD-K53414658 AGS 10 uM 6 h 0.0 0.0 0.0 0.26 0.94 0.28
9745 BRD-K53414658 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10219 BRD-K53414658 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.91
10799 BRD-K53414658 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10982 BRD-K53414658 HT29 10 uM 24 h 0.0 0.0 0.0 0.37 1.32 1.6
11507 BRD-K53414658 NCIH2073 10 uM 6 h 0.22 0.92 0.04 -0.37 -1.24 1.35
11779 BRD-K53414658 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12067 BRD-K53414658 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12330 BRD-K53414658 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12543 BRD-K53414658 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12808 BRD-K53414658 SW480 10 uM 6 h 0.24 0.99 0.09 0.0 0.0 0.0
13292 BRD-K53414658 U937 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13481 BRD-K53414658 VCAP 10 uM 24 h 0.25 1.03 0.14 0.27 0.94 0.29
90608 BRD-K53414658 HCT116 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90676 BRD-K53414658 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91513 BRD-K53414658 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91607 BRD-K53414658 HS578T 0.37 uM 6 h -0.2 -0.85 0.01 -0.29 -0.99 0.51
91775 BRD-K53414658 SKBR3 0.08 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
92917 BRD-K53414658 ASC 10 uM 24 h 0.0 0.0 0.0 0.21 0.73 0.03
92975 BRD-K53414658 CD34 3.33 uM 24 h 0.27 1.11 0.25 -0.29 -0.98 0.5
93202 BRD-K53414658 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93258 BRD-K53414658 JURKAT 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93385 BRD-K53414658 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93504 BRD-K53414658 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95708 BRD-K53414658 U2OS 1.11 uM 6 h 0.0 0.0 0.0 -0.27 -0.9 0.28
98095 BRD-K53414658 P1A82 1.11 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.43
124286 BRD-K53414658 A549 10 uM 24 h -0.3 -1.24 0.67 0.37 1.32 1.59
124317 BRD-K53414658 HEK293 10 uM 24 h 0.31 1.31 0.76 0.32 1.12 0.76
124351 BRD-K53414658 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124466 BRD-K53414658 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124486 BRD-K53414658 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
124546 BRD-K53414658 YAPC 10 uM 24 h -0.23 -0.97 0.11 0.4 1.41 2.18
132330 BRD-K53414658 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132389 BRD-K53414658 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.33 -1.09 0.85
132604 BRD-K53414658 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).