CMap Candidate Details

Structure:
CMap ID: C19446
Pert ID: BRD-K53508936
Compound Name: CTS-1027
Targets: MMP2; MMP3; MMP9; MMP13
MoA: Metalloproteinase inhibitor
SMILES: ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
InchiKey: ROSNVSQTEGHUKU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
125342 BRD-K53508936 HEK293 1.11 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
125363 BRD-K53508936 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125467 BRD-K53508936 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125479 BRD-K53508936 MDAMB231 0.04 uM 24 h -0.24 -0.99 0.13 0.29 1.02 0.48
125508 BRD-K53508936 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125535 BRD-K53508936 THP1 0.04 uM 24 h -0.26 -1.06 0.26 0.0 0.0 0.0
133351 BRD-K53508936 A375 0.01 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
133376 BRD-K53508936 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133406 BRD-K53508936 HA1E 0.01 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
133471 BRD-K53508936 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133499 BRD-K53508936 JURKAT 0.01 uM 24 h -0.27 -1.14 0.42 0.36 1.29 1.46
133534 BRD-K53508936 MCF10A 0.01 uM 24 h -0.25 -1.04 0.21 -0.35 -1.18 1.15
133653 BRD-K53508936 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).