CMap Candidate Details

Structure:
CMap ID: C19448
Pert ID: BRD-K53523901
Compound Name: arctigenin
Targets: CHUK; MAP2K1
MoA: MEK inhibitor
SMILES: COc1cc(C[C@@H]2[C@@H](Cc3ccc(OC)c(OC)c3)COC2=O)ccc1O
InchiKey: NQWVSMVXKMHKTF-JKSUJKDBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2900 BRD-K53523901 HA1E 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.46
3229 BRD-K53523901 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3524 BRD-K53523901 PC3 10 uM 24 h 0.0 0.0 0.0 0.19 0.69 0.01
3969 BRD-K53523901 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39143 BRD-K53523901 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39458 BRD-K53523901 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39711 BRD-K53523901 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40015 BRD-K53523901 HEPG2 10 uM 6 h -0.31 -1.28 0.75 -0.46 -1.56 15.65
40287 BRD-K53523901 HT29 10 uM 6 h 0.18 0.75 0.0 0.26 0.93 0.27
40478 BRD-K53523901 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
40825 BRD-K53523901 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41132 BRD-K53523901 NPC 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.11
41467 BRD-K53523901 SKB 10 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
53521 BRD-K53523901 HUH7 2.5 uM 24 h 0.3 1.25 0.53 -0.25 -0.83 0.16
53735 BRD-K53523901 PHH 2.5 uM 6 h 0.32 1.35 0.96 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).