CMap Candidate Details

Structure:
CMap ID: C19462
Pert ID: BRD-K53561341
Compound Name: KIN-001-220
Targets: --
MoA: --
SMILES: CCN1CCN(CC1)C(=O)Cc1ccc(Nc2ncc(F)c(Nc3ccc(cc3)C(=O)Nc3ccccc3Cl)n2)cc1
InchiKey: AKSIZPIFQAYJGF-UHFFFAOYSA-N
Compound Aliases: aurora-a-inhibitor-i

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
481 BRD-K53561341 BJAB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
527 BRD-K53561341 HBL1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
568 BRD-K53561341 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
619 BRD-K53561341 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
664 BRD-K53561341 MINO 10 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
711 BRD-K53561341 NALM6 10 uM 24 h 0.0 0.0 0.0 -0.19 -0.64 0.01
782 BRD-K53561341 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
802 BRD-K53561341 OCILY3 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
852 BRD-K53561341 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
899 BRD-K53561341 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
954 BRD-K53561341 TMD8 10 uM 4 h 0.0 0.0 0.0 -0.28 -0.93 0.35
33573 BRD-K53561341 A375 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.25
34380 BRD-K53561341 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34642 BRD-K53561341 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34908 BRD-K53561341 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.02 0.61
35582 BRD-K53561341 NEU 10 uM 24 h 0.24 1.02 0.13 0.0 0.0 0.0
36089 BRD-K53561341 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36586 BRD-K53561341 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36835 BRD-K53561341 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.91
91514 BRD-K53561341 BT20 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91580 BRD-K53561341 HS578T 2.22 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
91635 BRD-K53561341 MCF10A 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91692 BRD-K53561341 MDAMB231 10 uM 24 h -0.21 -0.88 0.03 -0.27 -0.9 0.28
91750 BRD-K53561341 SKBR3 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
94441 BRD-K53561341 A549 10 uM 24 h 0.17 0.73 0.0 -0.34 -1.15 1.07
94476 BRD-K53561341 ASC 3.33 uM 24 h -0.21 -0.89 0.03 -0.34 -1.13 1.0
94542 BRD-K53561341 CD34 10 uM 24 h 0.36 1.5 1.43 0.0 0.0 0.0
94633 BRD-K53561341 HEK293 10 uM 24 h 0.25 1.04 0.16 -0.28 -0.95 0.41
94684 BRD-K53561341 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94736 BRD-K53561341 HME1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94786 BRD-K53561341 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94829 BRD-K53561341 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94882 BRD-K53561341 JURKAT 0.12 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
94969 BRD-K53561341 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95089 BRD-K53561341 NPC 3.33 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
95155 BRD-K53561341 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95203 BRD-K53561341 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96012 BRD-K53561341 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).