CMap Candidate Details

Structure:
CMap ID: C01947
Pert ID: BRD-A79768653
Compound Name: sirolimus
Targets: FKBP1A; MTOR
MoA: MTOR inhibitor
SMILES: COC1CC(CC(C)C2CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C(C)C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N3CCCCC3C(=O)O2)OC)CCC1O
InchiKey: QFJCIRLUMZQUOT-XWBLMERNSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
165 BRD-A79768653 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
246 BRD-A79768653 OCILY10 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
399 BRD-A79768653 THP1 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
569 BRD-A79768653 K562 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
712 BRD-A79768653 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
853 BRD-A79768653 SKMEL5 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9312 BRD-A79768653 AGS 10 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.18
9616 BRD-A79768653 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10420 BRD-A79768653 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11368 BRD-A79768653 NCIH2073 10 uM 6 h -0.31 -1.27 0.74 0.0 0.0 0.0
11937 BRD-A79768653 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12224 BRD-A79768653 NOMO1 10 uM 6 h -0.33 -1.37 1.08 0.0 0.0 0.0
12689 BRD-A79768653 SW480 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.82 0.15
13166 BRD-A79768653 U937 10 uM 6 h 0.0 0.0 0.0 0.21 0.76 0.05
46539 BRD-A79768653 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
55129 BRD-A79768653 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
82822 BRD-A79768653 HA1E 4 uM 24 h 0.25 1.03 0.14 -0.33 -1.13 0.97
83012 BRD-A79768653 HEPG2 4 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
85243 BRD-A79768653 HCC515 4 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
85646 BRD-A79768653 PC3 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.14
87001 BRD-A79768653 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87320 BRD-A79768653 BJAB 2.5 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.43
87345 BRD-A79768653 HBL1 0.66 uM 24 h 0.22 0.93 0.05 0.27 0.94 0.3
87499 BRD-A79768653 MINO 2.5 uM 3 h 0.2 0.81 0.0 -0.35 -1.17 1.12
87647 BRD-A79768653 OCILY19 0.04 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
87699 BRD-A79768653 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87828 BRD-A79768653 TMD8 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90441 BRD-A79768653 HL60 10 uM 2 h 0.0 0.0 0.0 -0.31 -1.05 0.72
90559 BRD-A79768653 A549 0.01 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
90663 BRD-A79768653 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90792 BRD-A79768653 HPTEC 10 uM 6 h 0.0 0.0 0.0 0.29 1.02 0.49
91764 BRD-A79768653 SKBR3 0.37 uM 6 h -0.22 -0.9 0.04 -0.32 -1.08 0.8
92416 BRD-A79768653 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92476 BRD-A79768653 BT20 3.33 uM 24 h -0.29 -1.19 0.53 0.0 0.0 0.0
92590 BRD-A79768653 HS578T 3.33 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
92681 BRD-A79768653 LNCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93063 BRD-A79768653 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93341 BRD-A79768653 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93382 BRD-A79768653 NPC 10 uM 24 h 0.24 1.0 0.11 -0.29 -0.98 0.48
94084 BRD-A79768653 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94503 BRD-A79768653 ASC 10 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.3
94526 BRD-A79768653 CD34 10 uM 24 h -0.3 -1.27 0.74 -0.45 -1.53 15.35
94719 BRD-A79768653 HME1 10 uM 24 h 0.17 0.7 0.0 0.0 0.0 0.0
94814 BRD-A79768653 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95139 BRD-A79768653 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.2 0.72 0.02
95193 BRD-A79768653 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95988 BRD-A79768653 PHH 3.33 uM 24 h 0.21 0.89 0.02 0.33 1.19 1.01
98027 BRD-A79768653 MCF??7.00 0.125 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
98076 BRD-A79768653 P1A82 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
110390 BRD-A79768653 U2OS 20 uM 6 h 0.18 0.75 0.0 0.2 0.72 0.02
119738 BRD-A79768653 JURKAT 10 uM 24 h -0.27 -1.14 0.43 0.0 0.0 0.0
135138 BRD-A79768653 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135339 BRD-A79768653 YAPC 0.03 uM 24 h 0.22 0.9 0.03 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).