CMap Candidate Details

Structure:
CMap ID: C19499
Pert ID: BRD-K53665955
Compound Name: MK-5108
Targets: AURKA; AURKB
MoA: Aurora kinase inhibitor
SMILES: OC(=O)[C@@]1(Cc2cccc(Nc3nccs3)n2)CC[C@@H](CC1)Oc1cccc(Cl)c1F
InchiKey: LCVIRAZGMYMNNT-VVONHTQRSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
119437 BRD-K53665955 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119502 BRD-K53665955 HCC515 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119539 BRD-K53665955 HEPG2 10 uM 24 h 0.24 1.01 0.11 0.0 0.0 0.0
119634 BRD-K53665955 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121565 BRD-K53665955 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121607 BRD-K53665955 HA1E 1.11 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
121642 BRD-K53665955 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121684 BRD-K53665955 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129639 BRD-K53665955 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129731 BRD-K53665955 YAPC 0.74 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.46
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).