CMap Candidate Details

Structure:
CMap ID: C01951
Pert ID: BRD-A79981887
Compound Name: midodrine
Targets: ADRA1D; ADRA1B; ADRA1A
MoA: Adrenergic receptor agonist
SMILES: COc1ccc(OC)c(c1)C(O)CNC(=O)CN
InchiKey: PTKSEFOSCHHMPD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5414 BRD-A79981887 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5551 BRD-A79981887 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6492 BRD-A79981887 VCAP 10 uM 6 h 0.21 0.87 0.01 -0.31 -1.03 0.62
37555 BRD-A79981887 ASC 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.69
37856 BRD-A79981887 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38397 BRD-A79981887 NPC 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.08
38666 BRD-A79981887 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38890 BRD-A79981887 SKB 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.47
127373 BRD-A79981887 A375 10 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
127493 BRD-A79981887 HT29 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
127540 BRD-A79981887 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
127628 BRD-A79981887 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127713 BRD-A79981887 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135353 BRD-A79981887 A549 0.74 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.86
135384 BRD-A79981887 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135453 BRD-A79981887 MCF10A 0.25 uM 24 h 0.27 1.13 0.28 0.21 0.73 0.03
135483 BRD-A79981887 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135509 BRD-A79981887 THP1 2.22 uM 24 h -0.2 -0.82 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).