CMap Candidate Details

Structure:
CMap ID: C19515
Pert ID: BRD-K53737926
Compound Name: amitriptyline
Targets: CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; HRH1; HTR6; SLC6A2; SLC6A4
MoA: Norepinephrine inhibitor; Serotonin reuptake inhibitor; Serotonin receptor antagonist; Norepinephrine reuptake inhibitor
SMILES: CN(C)CCC=C1c2ccccc2CCc2ccccc12
InchiKey: KRMDCWKBEZIMAB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1440 BRD-K53737926 NPC 25 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
4443 BRD-K53737926 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4695 BRD-K53737926 PC3 10 uM 24 h 0.3 1.23 0.51 0.23 0.82 0.1
4938 BRD-K53737926 VCAP 10 uM 24 h -0.28 -1.16 0.48 -0.31 -1.03 0.64
37298 BRD-K53737926 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37691 BRD-K53737926 ASC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
37921 BRD-K53737926 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.25 0.88 0.19
38746 BRD-K53737926 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99648 BRD-K53737926 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
121567 BRD-K53737926 A375 10 uM 24 h 0.0 0.0 0.0 0.41 1.44 2.21
121609 BRD-K53737926 HA1E 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
121643 BRD-K53737926 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121663 BRD-K53737926 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121685 BRD-K53737926 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121709 BRD-K53737926 YAPC 10 uM 24 h 0.27 1.13 0.3 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).