CMap Candidate Details

Structure:
CMap ID: C19535
Pert ID: BRD-K53792571
Compound Name: inhibitor-BEC
Targets: ARG1; ARG2
MoA: Arginase inhibitor
SMILES: N[C@H](CSCCB(O)O)C(=O)O
InchiKey: OTJHLDXXJHAZTN-SCSAIBSYSA-N
Compound Aliases: inhibitor-bec

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8955 BRD-K53792571 A375 80 uM 24 h -0.24 -0.98 0.12 0.33 1.18 0.97
9102 BRD-K53792571 A549 80 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9442 BRD-K53792571 AGS 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9747 BRD-K53792571 H1299 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9891 BRD-K53792571 HA1E 80 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
10137 BRD-K53792571 HCC515 80 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
10534 BRD-K53792571 HCT116 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11148 BRD-K53792571 MCF??7.00 80 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.13
11780 BRD-K53792571 NCIH508 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12332 BRD-K53792571 NOMO1 80 uM 6 h -0.23 -0.95 0.09 0.0 0.0 0.0
12609 BRD-K53792571 PC3 80 uM 6 h 0.0 0.0 0.0 -0.25 -0.86 0.2
12809 BRD-K53792571 SW480 80 uM 6 h 0.24 1.01 0.12 0.26 0.92 0.25
12962 BRD-K53792571 THP1 80 uM 6 h 0.37 1.53 1.46 0.0 0.0 0.0
13294 BRD-K53792571 U937 80 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13635 BRD-K53792571 VCAP 80 uM 6 h 0.19 0.81 0.0 0.0 0.0 0.0
116462 BRD-K53792571 HEPG2 10 uM 24 h -0.26 -1.07 0.27 -0.43 -1.44 15.35
116512 BRD-K53792571 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).