CMap Candidate Details

Structure:
CMap ID: C19543
Pert ID: BRD-K53814070
Compound Name: ripasudil
Targets: ROCK1; ROCK2
MoA: Rho associated kinase inhibitor
SMILES: C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12
InchiKey: QSKQVZWVLOIIEV-NSHDSACASA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96872 BRD-K53814070 A375 10 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
124300 BRD-K53814070 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
124318 BRD-K53814070 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124419 BRD-K53814070 JURKAT 1.11 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
124488 BRD-K53814070 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.18 0.62 0.0
124548 BRD-K53814070 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132359 BRD-K53814070 A549 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132444 BRD-K53814070 HELA 2.22 uM 24 h 0.19 0.78 0.0 0.27 0.97 0.34
132464 BRD-K53814070 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
132495 BRD-K53814070 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.68
132524 BRD-K53814070 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
132572 BRD-K53814070 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.3
132607 BRD-K53814070 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).