CMap Candidate Details

Structure:
CMap ID: C19552
Pert ID: BRD-K53855319
Compound Name: SRT-1720
Targets: SIRT1
MoA: SIRT activator
SMILES: O=C(Nc1cc(CN2CCNCC2)cc(c1)-c1nc2ccccc2[nH]1)c1cnc2ccccc2n1
InchiKey: GXDSSUIUJKSVED-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9748 BRD-K53855319 H1299 12 uM 6 h 0.23 0.96 0.08 0.0 0.0 0.0
10062 BRD-K53855319 HA1E 12 uM 6 h 0.2 0.83 0.0 0.0 0.0 0.0
10984 BRD-K53855319 HT29 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11509 BRD-K53855319 NCIH2073 12 uM 6 h -0.2 -0.84 0.01 -0.29 -0.98 0.48
12069 BRD-K53855319 NCIH596 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12333 BRD-K53855319 NOMO1 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12810 BRD-K53855319 SW480 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13071 BRD-K53855319 THP1 12 uM 6 h 0.0 0.0 0.0 0.36 1.28 1.37
13295 BRD-K53855319 U937 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13636 BRD-K53855319 VCAP 12 uM 6 h 0.0 0.0 0.0 0.33 1.18 1.01
115631 BRD-K53855319 A375 0.125 uM 24 h 0.28 1.16 0.35 0.34 1.19 1.03
115670 BRD-K53855319 A549 12 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
115749 BRD-K53855319 HCC515 0.37 uM 24 h 0.23 0.96 0.08 0.34 1.2 1.07
115792 BRD-K53855319 HEPG2 1.25 uM 24 h 0.21 0.89 0.02 -0.22 -0.74 0.05
115881 BRD-K53855319 MCF??7.00 12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115920 BRD-K53855319 PC3 12 uM 24 h 0.25 1.05 0.16 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).