CMap Candidate Details

Structure:
CMap ID: C19553
Pert ID: BRD-K53857191
Compound Name: risperidone
Targets: ADRA1B; ADRA1A; DRD2; DRD3; DRD4; HRH1; HTR1A; HTR1D; HTR2A; HTR2C
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12
InchiKey: RAPZEAPATHNIPO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1433 BRD-K53857191 NPC 25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1923 BRD-K53857191 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24787 BRD-K53857191 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
25388 BRD-K53857191 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42106 BRD-K53857191 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42392 BRD-K53857191 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42712 BRD-K53857191 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43880 BRD-K53857191 PHH 10 uM 24 h 0.0 0.0 0.0 0.2 0.72 0.02
44137 BRD-K53857191 SKB 10 uM 24 h 0.26 1.09 0.23 0.41 1.44 2.21
98397 BRD-K53857191 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99649 BRD-K53857191 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124355 BRD-K53857191 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124422 BRD-K53857191 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.73
124452 BRD-K53857191 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.93 0.34
124491 BRD-K53857191 MDAMB231 3.33 uM 24 h -0.22 -0.93 0.07 -0.21 -0.71 0.03
124520 BRD-K53857191 PC3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124551 BRD-K53857191 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132333 BRD-K53857191 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132426 BRD-K53857191 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132466 BRD-K53857191 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132525 BRD-K53857191 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132610 BRD-K53857191 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).