CMap Candidate Details

Structure:
CMap ID: C01957
Pert ID: BRD-A80151636
Compound Name: bromocriptine
Targets: ADRA2A; ADRA2B; ADRA2C; DRD1; DRD2; DRD3; DRD4; DRD5; HTR1A; HTR1B; HTR1D; HTR2A; HTR2B; HTR2C
MoA: Dopamine receptor agonist
SMILES: CC(C)CC1N2C(=O)[C@](NC(=O)C3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(OC2(O)[C@@H]2CCCN2C1=O)C(C)C
InchiKey: OZVBMTJYIDMWIL-NXIPCUEUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5553 BRD-A80151636 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6493 BRD-A80151636 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37106 BRD-A80151636 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37556 BRD-A80151636 ASC 10 uM 24 h 0.22 0.9 0.02 0.31 1.09 0.67
37857 BRD-A80151636 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38398 BRD-A80151636 NPC 10 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
38667 BRD-A80151636 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38891 BRD-A80151636 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100338 BRD-A80151636 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.38 -1.29 1.53
125629 BRD-A80151636 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.15
125674 BRD-A80151636 HELA 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.81
125694 BRD-A80151636 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125728 BRD-A80151636 HUVEC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125774 BRD-A80151636 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125824 BRD-A80151636 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
125927 BRD-A80151636 YAPC 0.37 uM 24 h -0.22 -0.91 0.06 0.23 0.82 0.1
133663 BRD-A80151636 A549 0.08 uM 24 h -0.2 -0.84 0.01 0.2 0.7 0.01
133730 BRD-A80151636 HEK293 0.03 uM 24 h 0.25 1.04 0.15 0.0 0.0 0.0
133852 BRD-A80151636 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133910 BRD-A80151636 MDAMB231 0.03 uM 24 h -0.27 -1.14 0.42 -0.22 -0.73 0.04
133940 BRD-A80151636 PC3 0.74 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
133974 BRD-A80151636 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).