CMap Candidate Details

Structure:
CMap ID: C19570
Pert ID: BRD-K53913732
Compound Name: SB-408124
Targets: HCRTR1
MoA: Orexin receptor antagonist
SMILES: CN(C)c1ccc(NC(=O)Nc2cc(C)nc3c(F)cc(F)cc23)cc1
InchiKey: JTARFZSNUAGHRB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2901 BRD-K53913732 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.66
3230 BRD-K53913732 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
39459 BRD-K53913732 A549 10 uM 6 h -0.25 -1.05 0.24 -0.24 -0.81 0.14
39712 BRD-K53913732 ASC 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
40016 BRD-K53913732 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40288 BRD-K53913732 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40479 BRD-K53913732 MCF??7.00 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
40826 BRD-K53913732 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41133 BRD-K53913732 NPC 10 uM 24 h 0.0 0.0 0.0 0.37 1.29 1.49
41468 BRD-K53913732 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90370 BRD-K53913732 PC3 3.33 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.36
90411 BRD-K53913732 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96621 BRD-K53913732 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).