CMap Candidate Details

Structure:
CMap ID: C19592
Pert ID: BRD-K53959060
Compound Name: indirubin
Targets: CDK5; GSK3A; CDK1
MoA: CDK inhibitor; GSK-3 inhibitor
SMILES: ON=C1C(=C2C(=O)Nc3ccccc23)Nc4ccccc14
InchiKey: HBDSHCUSXQATPO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6891 BRD-K53959060 A375 10 uM 6 h 0.25 1.02 0.13 -0.36 -1.2 1.21
7178 BRD-K53959060 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7464 BRD-K53959060 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7686 BRD-K53959060 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.06 0.73
8014 BRD-K53959060 HT29 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.26 1.36
8180 BRD-K53959060 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.24 -0.79 0.11
8391 BRD-K53959060 PC3 10 uM 24 h 0.25 1.05 0.17 -0.32 -1.09 0.82
8830 BRD-K53959060 VCAP 10 uM 6 h 0.22 0.92 0.04 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).