CMap Candidate Details

Structure:
CMap ID: C19594
Pert ID: BRD-K53963539
Compound Name: vortioxetine
Targets: HTR1A; HTR1B; HTR1D; HTR7; SLC6A4
MoA: Serotonin receptor agonist; Serotonin receptor antagonist
SMILES: Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1
InchiKey: YQNWZWMKLDQSAC-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124275 BRD-K53963539 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124287 BRD-K53963539 A549 10 uM 24 h 0.0 0.0 0.0 0.37 1.32 1.71
124301 BRD-K53963539 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124319 BRD-K53963539 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124354 BRD-K53963539 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124385 BRD-K53963539 HT29 10 uM 24 h 0.23 0.97 0.08 -0.28 -0.94 0.36
124420 BRD-K53963539 JURKAT 0.125 uM 24 h -0.26 -1.08 0.29 -0.27 -0.92 0.33
124450 BRD-K53963539 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124467 BRD-K53963539 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.62
124489 BRD-K53963539 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
124519 BRD-K53963539 PC3 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
124549 BRD-K53963539 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132608 BRD-K53963539 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).