CMap Candidate Details

Structure:
CMap ID: C19599
Pert ID: BRD-K53979406
Compound Name: ALX-5407
Targets: SLC6A9
MoA: Glycine transporter inhibitor
SMILES: CN(CC[C@@H](Oc1ccc(cc1)-c1ccccc1)c1ccc(F)cc1)CC(O)=O
InchiKey: FDORQEIHOKEJNX-HSZRJFAPSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8831 BRD-K53979406 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.39 -1.32 1.71
124303 BRD-K53979406 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124356 BRD-K53979406 HELA 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124423 BRD-K53979406 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124469 BRD-K53979406 MCF??7.00 10 uM 24 h 0.22 0.91 0.03 0.26 0.91 0.23
124521 BRD-K53979406 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132334 BRD-K53979406 A375 0.01 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
132361 BRD-K53979406 A549 0.08 uM 24 h -0.17 -0.71 0.0 0.27 0.95 0.31
132427 BRD-K53979406 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132467 BRD-K53979406 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132497 BRD-K53979406 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132555 BRD-K53979406 MDAMB231 0.01 uM 24 h 0.24 1.02 0.12 0.29 1.02 0.49
132611 BRD-K53979406 THP1 2.22 uM 24 h 0.29 1.2 0.42 -0.16 -0.53 0.0
132643 BRD-K53979406 YAPC 2.22 uM 24 h -0.17 -0.71 0.0 0.32 1.13 0.85
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).