CMap Candidate Details

Structure:
CMap ID: C01968
Pert ID: BRD-A80641450
Compound Name: FR-139317
Targets: EDNRA
MoA: Endothelin receptor antagonist
SMILES: CC(C)CC(NC(=O)N1CCCCCC1)C(=O)NC(Cc2cn(C)c3ccccc23)C(=O)NC(Cc4ccccn4)C(=O)O
InchiKey: LIOKMIQQPDDTNO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1709 BRD-A80641450 HA1E 10 uM 6 h -0.17 -0.71 0.0 0.0 0.0 0.0
2053 BRD-A80641450 HCC515 10 uM 6 h 0.0 0.0 0.0 0.21 0.74 0.03
2285 BRD-A80641450 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2770 BRD-A80641450 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39068 BRD-A80641450 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39283 BRD-A80641450 A549 10 uM 24 h -0.26 -1.09 0.33 -0.3 -1.02 0.61
39596 BRD-A80641450 ASC 10 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
39916 BRD-A80641450 HEPG2 10 uM 6 h 0.22 0.91 0.03 -0.26 -0.86 0.21
40200 BRD-A80641450 HT29 10 uM 6 h 0.0 0.0 0.0 -0.41 -1.38 2.02
40438 BRD-A80641450 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40719 BRD-A80641450 NEU 10 uM 24 h -0.25 -1.02 0.19 0.25 0.88 0.19
41020 BRD-A80641450 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41343 BRD-A80641450 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100341 BRD-A80641450 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).