CMap Candidate Details

Structure:
CMap ID: C01971
Pert ID: BRD-A80775386
Compound Name: hyperforin
Targets: ALOX5; PTGS1; NR1I2
MoA: Lipoxygenase inhibitor; Cyclooxygenase inhibitor; Dopamine uptake inhibitor; Serotonin reuptake inhibitor; Interleukin receptor antagonist
SMILES: CC(C)C(=O)[C@@]12C(=O)C(CC=C(C)C)C(=O)[C@@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]1(C)CCC=C(C)C)C2=O
InchiKey: GQRREYKSPJMLAW-KZFONMTISA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33633 BRD-A80775386 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33757 BRD-A80775386 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34010 BRD-A80775386 ASC 10 uM 24 h -0.21 -0.86 0.02 -0.29 -0.98 0.48
34288 BRD-A80775386 HA1E 10 uM 6 h 0.21 0.86 0.01 0.0 0.0 0.0
34524 BRD-A80775386 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.41 -1.39 2.02
34792 BRD-A80775386 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35066 BRD-A80775386 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35281 BRD-A80775386 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.96 0.44
35703 BRD-A80775386 NPC 10 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
36049 BRD-A80775386 PC3 10 uM 6 h 0.25 1.05 0.18 -0.44 -1.46 15.35
36168 BRD-A80775386 PHH 10 uM 24 h 0.0 0.0 0.0 0.27 0.97 0.35
36461 BRD-A80775386 SKB 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.66 0.01
36749 BRD-A80775386 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).