CMap Candidate Details

Structure:
CMap ID: C19738
Pert ID: BRD-K54416256
Compound Name: methimazole
Targets: TPO
MoA: Anti-thyroid agent
SMILES: Cn1cc[nH]c1=S
InchiKey: PMRYVIKBURPHAH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
51041 BRD-K54416256 VCAP 10 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
91226 BRD-K54416256 HUH7 30 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
124321 BRD-K54416256 HEK293 0.04 uM 24 h 0.31 1.28 0.63 -0.22 -0.73 0.04
124357 BRD-K54416256 HELA 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124387 BRD-K54416256 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124424 BRD-K54416256 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
132335 BRD-K54416256 A375 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132362 BRD-K54416256 A549 0.08 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
132392 BRD-K54416256 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132498 BRD-K54416256 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132526 BRD-K54416256 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.22
132556 BRD-K54416256 MDAMB231 0.08 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
132573 BRD-K54416256 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
132612 BRD-K54416256 THP1 0.25 uM 24 h -0.31 -1.29 0.79 -0.31 -1.06 0.72
132644 BRD-K54416256 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).