CMap Candidate Details

Structure:
CMap ID: C19749
Pert ID: BRD-K54462405
Compound Name: doxepin
Targets: HRH1; HRH2; SLC6A2; SLC6A4
MoA: Histamine receptor antagonist
SMILES: CN(C)CC/C=C/1c2ccccc2COc3ccccc13
InchiKey: ODQWQRRAPPTVAG-GZTJUZNOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2902 BRD-K54462405 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.83
3233 BRD-K54462405 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3632 BRD-K54462405 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3833 BRD-K54462405 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41949 BRD-K54462405 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42394 BRD-K54462405 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43205 BRD-K54462405 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43580 BRD-K54462405 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43882 BRD-K54462405 PHH 10 uM 24 h -0.25 -1.03 0.19 -0.31 -1.06 0.72
44139 BRD-K54462405 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
49859 BRD-K54462405 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50552 BRD-K54462405 HT29 10 uM 6 h -0.2 -0.83 0.0 0.0 0.0 0.0
99657 BRD-K54462405 U2OS 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).