CMap Candidate Details

Structure:
CMap ID: C19845
Pert ID: BRD-K54759182
Compound Name: dosulepin
Targets: SLC6A2; SLC6A4
MoA: Tricyclic antidepressant; Serotonin reuptake inhibitor; Norepinephrine reuptake inhibitor
SMILES: CN(C)CCC=C1/c2ccccc2CSc2ccccc12
InchiKey: PHTUQLWOUWZIMZ-GZTJUZNOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3236 BRD-K54759182 HCC515 10 uM 24 h 0.27 1.15 0.32 0.0 0.0 0.0
3835 BRD-K54759182 VCAP 10 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
41951 BRD-K54759182 A549 10 uM 24 h 0.0 0.0 0.0 -0.2 -0.67 0.01
42398 BRD-K54759182 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42717 BRD-K54759182 HEPG2 10 uM 6 h -0.26 -1.1 0.34 0.0 0.0 0.0
43583 BRD-K54759182 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.15
43886 BRD-K54759182 PHH 10 uM 24 h -0.21 -0.86 0.02 -0.26 -0.89 0.26
44143 BRD-K54759182 SKB 10 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
99662 BRD-K54759182 U2OS 6.66 uM 6 h -0.19 -0.79 0.0 0.0 0.0 0.0
121612 BRD-K54759182 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121688 BRD-K54759182 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129585 BRD-K54759182 A375 0.74 uM 24 h 0.25 1.05 0.17 -0.32 -1.07 0.76
129610 BRD-K54759182 HELA 0.01 uM 24 h 0.0 0.0 0.0 -0.19 -0.63 0.0
129643 BRD-K54759182 HT29 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129701 BRD-K54759182 PC3 0.01 uM 24 h -0.26 -1.08 0.3 0.0 0.0 0.0
129734 BRD-K54759182 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).