CMap Candidate Details

Structure:
CMap ID: C19847
Pert ID: BRD-K54770957
Compound Name: etoricoxib
Targets: PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: Cc1ccc(cn1)-c1ncc(Cl)cc1-c1ccc(cc1)S(C)(=O)=O
InchiKey: MNJVRJDLRVPLFE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
91196 BRD-K54770957 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
124304 BRD-K54770957 HA1E 10 uM 24 h 0.17 0.71 0.0 -0.26 -0.89 0.26
124388 BRD-K54770957 HT29 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
124425 BRD-K54770957 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124492 BRD-K54770957 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124522 BRD-K54770957 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132336 BRD-K54770957 A375 0.08 uM 24 h 0.0 0.0 0.0 0.34 1.22 1.15
132363 BRD-K54770957 A549 2.22 uM 24 h -0.31 -1.28 0.76 -0.23 -0.77 0.08
132428 BRD-K54770957 HEK293 0.25 uM 24 h -0.25 -1.03 0.19 0.25 0.9 0.21
132447 BRD-K54770957 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132499 BRD-K54770957 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
132527 BRD-K54770957 MCF??7.00 2.22 uM 24 h -0.35 -1.45 1.43 0.34 1.19 1.01
132613 BRD-K54770957 THP1 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132645 BRD-K54770957 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).