CMap Candidate Details

Structure:
CMap ID: C01986
Pert ID: BRD-A81370665
Compound Name: BI-D1870
Targets: RPS6KA1; RPS6KA2; RPS6KA3
MoA: Ribosomal protein inhibitor
SMILES: CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12
InchiKey: DTEKTGDVSARYDS-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
44 BRD-A81370665 BJAB 2.5 uM 4 h 0.0 0.0 0.0 -0.29 -0.98 0.47
109 BRD-A81370665 HBL1 10 uM 4 h 0.0 0.0 0.0 -0.41 -1.37 2.02
145 BRD-A81370665 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
166 BRD-A81370665 KMS34 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
208 BRD-A81370665 NALM6 10 uM 24 h 0.27 1.11 0.25 -0.25 -0.83 0.15
247 BRD-A81370665 OCILY10 10 uM 24 h 0.22 0.93 0.05 -0.38 -1.28 1.45
306 BRD-A81370665 OCILY19 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
324 BRD-A81370665 OCILY3 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
364 BRD-A81370665 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.27 0.94 0.29
417 BRD-A81370665 THP1 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
436 BRD-A81370665 TMD8 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).