CMap Candidate Details

Structure:
CMap ID: C01988
Pert ID: BRD-A81377415
Compound Name: BRD-A81377415
Targets: CLK1; DYRK1A; CLK4; DYRK1B
MoA: CLK inhibitor; DYRK inhibitor
SMILES: C(Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1)C1CCOC1
InchiKey: ADJWQFUAOONPHD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
16188 BRD-A81377415 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
16549 BRD-A81377415 A549 10 uM 6 h -0.3 -1.26 0.72 0.26 0.94 0.28
16878 BRD-A81377415 HCC515 10 uM 6 h 0.28 1.16 0.34 -0.3 -1.0 0.54
17204 BRD-A81377415 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
17543 BRD-A81377415 HT29 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.05
17880 BRD-A81377415 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
18213 BRD-A81377415 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
18673 BRD-A81377415 VCAP 10 uM 6 h 0.23 0.97 0.08 0.24 0.86 0.15
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).