CMap Candidate Details

Structure:
CMap ID: C19908
Pert ID: BRD-K54997624
Compound Name: alpelisib
Targets: PIK3CA
MoA: PI3K inhibitor
SMILES: Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(c1)C(C)(C)C(F)(F)F
InchiKey: STUWGJZDJHPWGZ-LBPRGKRZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
480 BRD-K54997624 BJAB 0.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
526 BRD-K54997624 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
567 BRD-K54997624 K562 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.79 0.1
618 BRD-K54997624 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
663 BRD-K54997624 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
710 BRD-K54997624 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
753 BRD-K54997624 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.21 0.74 0.04
824 BRD-K54997624 OCILY3 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
851 BRD-K54997624 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
898 BRD-K54997624 THP1 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
934 BRD-K54997624 TMD8 10 uM 24 h 0.19 0.81 0.0 -0.2 -0.69 0.02
92004 BRD-K54997624 A375 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92048 BRD-K54997624 BT20 10 uM 3 h -0.26 -1.09 0.32 -0.23 -0.77 0.08
92079 BRD-K54997624 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92113 BRD-K54997624 HCC515 10 uM 24 h 0.22 0.92 0.04 -0.23 -0.79 0.1
92147 BRD-K54997624 HS578T 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92198 BRD-K54997624 HT29 3.33 uM 24 h -0.26 -1.08 0.3 -0.21 -0.72 0.04
92221 BRD-K54997624 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.96 0.42
92277 BRD-K54997624 MCF??7.00 0.12 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92320 BRD-K54997624 MDAMB231 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92351 BRD-K54997624 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92396 BRD-K54997624 SKBR3 0.12 uM 3 h 0.0 0.0 0.0 -0.26 -0.89 0.26
95856 BRD-K54997624 NPC 0.25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95922 BRD-K54997624 YAPC 0.25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95954 BRD-K54997624 A549 0.25 uM 6 h -0.28 -1.15 0.43 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).