CMap Candidate Details

Structure:
CMap ID: C19916
Pert ID: BRD-K55026842
Compound Name: azacitidine
Targets: DNMT1
MoA: DNA methyltransferase inhibitor
SMILES: Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1
InchiKey: NMUSYJAQQFHJEW-ARQDHWQXSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95524 BRD-K55026842 A549 1.11 uM 48 h 0.0 0.0 0.0 -0.23 -0.79 0.11
95648 BRD-K55026842 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.43 -1.43 15.35
124279 BRD-K55026842 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124324 BRD-K55026842 HEK293 10 uM 24 h 0.29 1.2 0.43 -0.34 -1.15 1.07
124362 BRD-K55026842 HELA 1.11 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
124390 BRD-K55026842 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124430 BRD-K55026842 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124524 BRD-K55026842 PC3 0.125 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
132396 BRD-K55026842 HA1E 2.22 uM 24 h -0.24 -1.0 0.15 0.25 0.88 0.18
132502 BRD-K55026842 MCF10A 0.25 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
132531 BRD-K55026842 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 -0.37 -1.24 1.35
132559 BRD-K55026842 MDAMB231 0.74 uM 24 h 0.31 1.31 0.76 0.0 0.0 0.0
132618 BRD-K55026842 THP1 0.74 uM 24 h 0.31 1.31 0.77 -0.26 -0.86 0.21
132647 BRD-K55026842 YAPC 2.22 uM 24 h 0.26 1.1 0.24 -0.34 -1.14 1.03
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).