CMap Candidate Details

Structure:
CMap ID: C02001
Pert ID: BRD-A81772229
Compound Name: simvastatin
Targets: HMGCR
MoA: HMGCR inhibitor
SMILES: CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C12
InchiKey: RYMZZMVNJRMUDD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6698 BRD-A81772229 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6958 BRD-A81772229 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
7270 BRD-A81772229 HA1E 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
7597 BRD-A81772229 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.86 0.21
7811 BRD-A81772229 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8065 BRD-A81772229 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8332 BRD-A81772229 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8626 BRD-A81772229 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91386 BRD-A81772229 HUH7 1.11 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).