CMap Candidate Details

Structure:
CMap ID: C02006
Pert ID: BRD-A82035391
Compound Name: tolvaptan
Targets: AVPR1A; AVPR2
MoA: Vasopressin receptor antagonist
SMILES: Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCC(O)c3cc(Cl)ccc23)c(C)c1
InchiKey: GYHCTFXIZSNGJT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126369 BRD-A82035391 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126391 BRD-A82035391 A549 10 uM 24 h -0.29 -1.22 0.6 0.38 1.33 1.72
126460 BRD-A82035391 HEK293 3.33 uM 24 h 0.0 0.0 0.0 -0.38 -1.29 1.53
126503 BRD-A82035391 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126544 BRD-A82035391 MCF??7.00 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126564 BRD-A82035391 MDAMB231 10 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
134414 BRD-A82035391 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134443 BRD-A82035391 HELA 0.08 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
134527 BRD-A82035391 HUVEC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134553 BRD-A82035391 MCF10A 0.25 uM 24 h -0.2 -0.85 0.01 0.28 0.98 0.37
134638 BRD-A82035391 PC3 2.22 uM 24 h 0.26 1.09 0.23 0.0 0.0 0.0
134663 BRD-A82035391 YAPC 0.08 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.29
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).