CMap Candidate Details

Structure:
CMap ID: C02014
Pert ID: BRD-A82371568
Compound Name: clofarabine
Targets: POLA1; RRM1; RRM2
MoA: Ribonucleoside reductase inhibitor
SMILES: Nc1nc(Cl)nc2n(cnc12)C3OC(CO)C(O)C3F
InchiKey: WDDPHFBMKLOVOX-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1516 BRD-A82371568 HA1E 10 uM 24 h -0.28 -1.15 0.45 -0.28 -0.94 0.39
2055 BRD-A82371568 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2352 BRD-A82371568 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2773 BRD-A82371568 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39071 BRD-A82371568 A375 10 uM 6 h 0.2 0.82 0.0 -0.53 -1.77 15.65
39285 BRD-A82371568 A549 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
39599 BRD-A82371568 ASC 10 uM 24 h -0.29 -1.22 0.62 0.0 0.0 0.0
39918 BRD-A82371568 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40203 BRD-A82371568 HT29 10 uM 6 h 0.0 0.0 0.0 -0.35 -1.19 1.15
40579 BRD-A82371568 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.37 -1.24 1.31
40722 BRD-A82371568 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41023 BRD-A82371568 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41346 BRD-A82371568 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100349 BRD-A82371568 U2OS 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).