CMap Candidate Details

Structure:
CMap ID: C20200
Pert ID: BRD-K55930204
Compound Name: phenytoin
Targets: SCN1A; SCN2A; SCN5A
MoA: Hydantoin antiepileptic
SMILES: O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1
InchiKey: CXOFVDLJLONNDW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
50027 BRD-K55930204 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50380 BRD-K55930204 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
51045 BRD-K55930204 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90981 BRD-K55930204 HUH7 12.5 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99675 BRD-K55930204 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123787 BRD-K55930204 A375 0.125 uM 24 h 0.3 1.25 0.56 0.25 0.87 0.18
123885 BRD-K55930204 HEK293 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123984 BRD-K55930204 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124040 BRD-K55930204 MCF10A 10 uM 24 h 0.19 0.81 0.0 0.29 1.03 0.52
124167 BRD-K55930204 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124220 BRD-K55930204 YAPC 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
132159 BRD-K55930204 HA1E 0.08 uM 24 h 0.18 0.76 0.0 0.0 0.0 0.0
132187 BRD-K55930204 HELA 0.01 uM 24 h 0.26 1.08 0.21 0.3 1.06 0.61
132218 BRD-K55930204 HT29 0.08 uM 24 h 0.31 1.27 0.58 0.0 0.0 0.0
132248 BRD-K55930204 MCF??7.00 0.08 uM 24 h -0.2 -0.84 0.01 -0.24 -0.8 0.12
132270 BRD-K55930204 MDAMB231 0.01 uM 24 h 0.32 1.32 0.82 -0.29 -0.98 0.5
132287 BRD-K55930204 PC3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).