CMap Candidate Details

Structure:
CMap ID: C20208
Pert ID: BRD-K55966568
Compound Name: orantinib
Targets: FGFR1; FGFR2; KDR; PDGFRA; PDGFRB; AURKA; AURKB
MoA: FGFR inhibitor; PDGFR inhibitor; VEGFR inhibitor
SMILES: Cc1[nH]c(C=C2/C(=O)Nc3ccccc23)c(C)c1CCC(O)=O
InchiKey: NHFDRBXTEDBWCZ-ZROIWOOFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9104 BRD-K55966568 A549 6.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9447 BRD-K55966568 AGS 6.66 uM 6 h 0.26 1.08 0.22 -0.27 -0.91 0.3
9753 BRD-K55966568 H1299 6.66 uM 6 h 0.23 0.95 0.06 0.37 1.32 1.6
10195 BRD-K55966568 HCC515 6.66 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
10538 BRD-K55966568 HCT116 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10804 BRD-K55966568 HEPG2 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11513 BRD-K55966568 NCIH2073 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11785 BRD-K55966568 NCIH508 6.66 uM 6 h 0.0 0.0 0.0 -0.37 -1.24 1.3
12074 BRD-K55966568 NCIH596 6.66 uM 6 h 0.0 0.0 0.0 -0.35 -1.16 1.11
12336 BRD-K55966568 NOMO1 6.66 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12815 BRD-K55966568 SW480 6.66 uM 6 h 0.0 0.0 0.0 0.27 0.96 0.33
13484 BRD-K55966568 VCAP 6.66 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123552 BRD-K55966568 HEK293 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123607 BRD-K55966568 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123634 BRD-K55966568 HT29 10 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.46
123672 BRD-K55966568 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123755 BRD-K55966568 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131966 BRD-K55966568 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132002 BRD-K55966568 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
132068 BRD-K55966568 MCF??7.00 0.74 uM 24 h 0.29 1.2 0.44 0.0 0.0 0.0
132099 BRD-K55966568 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).