CMap Candidate Details

Structure:
CMap ID: C20279
Pert ID: BRD-K56195681
Compound Name: losmapimod
Targets: MAPK14
MoA: P38 MAPK inhibitor
SMILES: Cc1c(F)cc(cc1-c1ccc(cn1)C(=O)NCC(C)(C)C)C(=O)NC1CC1
InchiKey: KKYABQBFGDZVNQ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
95323 BRD-K56195681 A549 10 uM 48 h 0.0 0.0 0.0 -0.28 -0.94 0.37
95375 BRD-K56195681 MCF??7.00 10 uM 6 h -0.26 -1.06 0.26 0.2 0.7 0.01
95405 BRD-K56195681 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.15
95827 BRD-K56195681 A375 0.25 uM 6 h 0.0 0.0 0.0 0.25 0.89 0.21
95857 BRD-K56195681 NPC 0.25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123867 BRD-K56195681 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
123889 BRD-K56195681 HEK293 10 uM 24 h 0.0 0.0 0.0 0.31 1.09 0.67
123988 BRD-K56195681 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124044 BRD-K56195681 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
124117 BRD-K56195681 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124171 BRD-K56195681 THP1 1.11 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
124224 BRD-K56195681 YAPC 3.33 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
132188 BRD-K56195681 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.33
132221 BRD-K56195681 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132290 BRD-K56195681 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).