CMap Candidate Details

Structure:
CMap ID: C02031
Pert ID: BRD-A83081521
Compound Name: finasteride
Targets: SRD5A1; SRD5A2
MoA: 5 alpha reductase inhibitor
SMILES: CC(C)(C)NC(=O)[C@H]1CCC2C3CCC4NC(=O)C=C[C@]4(C)C3CC[C@]12C
InchiKey: DBEPLOCGEIEOCV-BYQKQGHSSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4324 BRD-A83081521 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
4865 BRD-A83081521 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37557 BRD-A83081521 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37858 BRD-A83081521 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38399 BRD-A83081521 NPC 10 uM 24 h 0.18 0.73 0.0 0.0 0.0 0.0
125557 BRD-A83081521 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125635 BRD-A83081521 HEK293 10 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
125705 BRD-A83081521 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.21
125791 BRD-A83081521 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
125813 BRD-A83081521 MCF??7.00 10 uM 24 h -0.23 -0.94 0.08 -0.3 -1.0 0.55
125885 BRD-A83081521 THP1 0.125 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
125904 BRD-A83081521 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.26
133655 BRD-A83081521 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133680 BRD-A83081521 HA1E 0.25 uM 24 h 0.25 1.04 0.14 0.0 0.0 0.0
133749 BRD-A83081521 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133781 BRD-A83081521 HT29 0.01 uM 24 h -0.28 -1.17 0.49 -0.25 -0.83 0.16
133813 BRD-A83081521 JURKAT 0.08 uM 24 h 0.34 1.43 1.1 0.0 0.0 0.0
133897 BRD-A83081521 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.33 1.18 1.01
133931 BRD-A83081521 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).