CMap Candidate Details

Structure:
CMap ID: C20328
Pert ID: BRD-K56334280
Compound Name: amonafide
Targets: TOP2A
MoA: Topoisomerase inhibitor
SMILES: CN(C)CCN1C(=O)c2cccc3cc(N)cc(C1=O)c23
InchiKey: UPALIKSFLSVKIS-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
29889 BRD-K56334280 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
30218 BRD-K56334280 A549 10 uM 6 h 0.2 0.84 0.0 0.26 0.92 0.25
30785 BRD-K56334280 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.13 0.97
31079 BRD-K56334280 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
31386 BRD-K56334280 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.52
31507 BRD-K56334280 HT29 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.8
32046 BRD-K56334280 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33065 BRD-K56334280 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33313 BRD-K56334280 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123888 BRD-K56334280 HEK293 3.33 uM 24 h 0.28 1.17 0.38 -0.39 -1.32 1.71
123938 BRD-K56334280 HELA 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.5
123987 BRD-K56334280 JURKAT 3.33 uM 24 h -0.22 -0.93 0.07 -0.33 -1.11 0.91
124043 BRD-K56334280 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.24
124150 BRD-K56334280 PC3 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.75
124170 BRD-K56334280 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124223 BRD-K56334280 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132271 BRD-K56334280 MDAMB231 2.22 uM 24 h 0.26 1.08 0.21 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).