CMap Candidate Details

Structure:
CMap ID: C20333
Pert ID: BRD-K56343971
Compound Name: vemurafenib
Targets: BRAF
MoA: RAF inhibitor
SMILES: CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
InchiKey: GPXBXXGIAQBQNI-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1167 BRD-K56343971 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.2 0.72 0.03
9105 BRD-K56343971 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9449 BRD-K56343971 AGS 10 uM 6 h -0.23 -0.95 0.09 0.0 0.0 0.0
9755 BRD-K56343971 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10540 BRD-K56343971 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11105 BRD-K56343971 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11515 BRD-K56343971 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12076 BRD-K56343971 NCIH596 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.12 0.96
12338 BRD-K56343971 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12613 BRD-K56343971 PC3 10 uM 6 h 0.0 0.0 0.0 0.23 0.83 0.12
12817 BRD-K56343971 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13301 BRD-K56343971 U937 10 uM 6 h 0.21 0.89 0.02 0.0 0.0 0.0
13486 BRD-K56343971 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34129 BRD-K56343971 ASC 10 uM 24 h 0.24 0.99 0.1 0.0 0.0 0.0
35585 BRD-K56343971 NEU 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
35802 BRD-K56343971 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36288 BRD-K56343971 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91515 BRD-K56343971 BT20 10 uM 24 h 0.2 0.81 0.0 -0.24 -0.81 0.13
91752 BRD-K56343971 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91982 BRD-K56343971 A375 0.37 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
92087 BRD-K56343971 HCC515 10 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
92126 BRD-K56343971 HS578T 10 uM 24 h -0.3 -1.23 0.64 0.0 0.0 0.0
92228 BRD-K56343971 MCF10A 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92304 BRD-K56343971 MDAMB231 10 uM 3 h 0.0 0.0 0.0 0.31 1.11 0.72
95399 BRD-K56343971 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.46 -1.56 15.65
116054 BRD-K56343971 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116142 BRD-K56343971 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.4 2.02
123890 BRD-K56343971 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123990 BRD-K56343971 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124172 BRD-K56343971 THP1 10 uM 24 h -0.25 -1.06 0.26 0.0 0.0 0.0
124225 BRD-K56343971 YAPC 10 uM 24 h -0.23 -0.96 0.09 -0.28 -0.93 0.35
132189 BRD-K56343971 HELA 2.22 uM 24 h 0.27 1.14 0.32 -0.26 -0.88 0.26
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).