CMap Candidate Details

Structure:
CMap ID: C20358
Pert ID: BRD-K56405753
Compound Name: MK-2461
Targets: FGFR1; FGFR3; FGFR2; FLT1; FLT3; MET
MoA: FGFR inhibitor; VEGFR inhibitor
SMILES: CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1
InchiKey: JGEBLDKNWBUGRZ-HXUWFJFHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123790 BRD-K56405753 A375 10 uM 24 h 0.19 0.78 0.0 -0.34 -1.16 1.11
123831 BRD-K56405753 A549 0.04 uM 24 h 0.25 1.04 0.15 -0.33 -1.12 0.94
123868 BRD-K56405753 HA1E 10 uM 24 h 0.22 0.92 0.04 -0.37 -1.24 1.3
123891 BRD-K56405753 HEK293 10 uM 24 h 0.26 1.1 0.24 -0.32 -1.07 0.76
123960 BRD-K56405753 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123991 BRD-K56405753 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124045 BRD-K56405753 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124173 BRD-K56405753 THP1 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
124226 BRD-K56405753 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132190 BRD-K56405753 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.42 1.47 2.24
132250 BRD-K56405753 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
132272 BRD-K56405753 MDAMB231 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132292 BRD-K56405753 PC3 2.22 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).